Education:

Research Experience:

2/2021 – Present Chinese Academy of Sciences, Beijing, China

Principal Investigator in Institute of Zoology

10/2019 – 1/2021 University of California, San Diego, United States

Postdoctoral Fellow in Division of Biological Sciences, laboratory of Dr. Omar S. Akbari.

Project: Genetic basis of mosquito olfaction and behavior using genome engineering technologies.

8/2016 – 10/2019 Harvard University, Cambridge, United States

Postdoctoral Fellow in Rowland Institute, laboratory of Dr. Robert M. Brucker.

Project: Experimental testing microbe function: pesticides metabolism and speciation.

9/2015 – 5/2016 Yale University, New Haven, United States

Joint Ph.D. student in Infection of Disease, laboratory of Dr. Erol Fikrig.

Project: Exploring proteins that facilitate Plasmodium transmission from mosquito to mammal.

6/2011 – 9/2015 Chinese Academy of Sciences, Beijing, China

Ph.D. student in Institute of Zoology, laboratory of Dr. Da-Wei Huang.

Project: Functions of phage to endosymbiont and insect host.

Research Areas:

Evolutionary Biology; Entomology; Microbiology; Genetic engineering; Genomics;

Publications (^#co-first, *co-corresponding):

In English

Publications:

20. Tao Wang; Xin-Rui Ren; Jin Geng; Yun-Ru Gao; Luo-Nan Wu; Guan-Hong Wang; Da-Wei Huang; Jinhua Xiao. 2023. Adaptation of intestinal microbiota and metabolome to divergent mitochondrial DNA in larvae of black soldier fly (Hermetia illucens). (submitted to Science of The Total Environment).

19. Zhengyu Zhu, Runbiao Wu, Guan-Hong Wang. 2023. Genome Sequence of Staphylococcus nepalensis ZZ-2023a, Isolated from Nasonia vitripennis. (In press @ Microbiology Resource Announcements).

18. Runbiao Wu, Zhengyu Zhu, Guan-Hong Wang. 2023. Genome Sequence of Providencia stuartii, Isolated from the wasp Nasonia vitripennis. Microbiology Resource Announcements.

17. Zhengyu Zhu, Dandan Wang, Yanjun Liu, Guan-Hong Wang. 2023. Rearing method of germ-free Nasonia wasp. JoVE (197), e65292.

16. Ronger Zheng, Qiqi Wang, Runbiao Wu, Prasad N Paradkar, Ary A Hoffmann, Guan-Hong Wang*. Holobiont manipulation to combat vector-borne disease. The ISME Journal.

15. Jiahui Wu, Qiqi Wang, Dandan Wang, Adam CN Wong, Guan-Hong Wang*. 2022. Axenic and gnotobiotic insect technologies in host-microbiota interaction research. Trends in Microbiology.

14. Zhengyu Zhu, Yanjun Liu, Haoyuan Hu, Guan-Hong Wang*. 2023. Nasonia-microbiome associations: a model for evolutionary hologenomics research. Trends in Parasitology 39:4-17.

13. Guan-Hong Wang*, Jie Du, Chenyi Chu, Mukund Madhav,Grant L. Hughes, Jackson Champer* 2022. Symbionts and gene drive: two strategies to combat vector-borne disease. Trends in Genetics 38:708-23.

12. Wang, G.-H.*, and R. M. Brucker*. An optimized method for Nasonia germ-free rearing. 2022. Scientific Reports 12:219

11. Wang, G.-H.#, Stephanie Gamez#, Robyn Raban#, John Marshall, Luke Alphey, Ming Li, Jason Rasgon, Omar S. Akbari*. 2021. Combating mosquito-borne pathogens using genetic control technologies. Nature Communications 12, 4388.

10. Wang G-H, Dittmer J, Douglas B, Huang L, Brucker RM*. 2021. Coadaptation between host genome and microbiome under long-term xenobiotic-induced selection. Science Advances 7, eabd4473.

9. Wang, G.-H., B. M. Berdy, O. Velasquez, N. Jovanovic, S. Alkhalifa, K. P. C. Minbiole, and R. M. Brucker*. 2020. Changes in Microbiome Confer Multigenerational Host Resistance after Sub-toxic Pesticide Exposure. Cell Host & Microbe 27:213-224.e217.

8. Wang, G.-H., and R. M. Brucker*. 2019a. Genome sequence of Enterococcus faecalis NVIT04, isolated from Nasonia vitripennis. Microbiology Resource Announcements 8:e01156-01118.

7. Wang, G.-H., and R. M. Brucker*. 2019b. Genome sequence of Providencia rettgeri NVIT03, isolated from Nasonia vitripennis. Microbiology Resource Announcements 8:e01157-01118.

6. Huan Li, Tongtong Li, Xiangzhen Li*, Guanhong Wang, Qiang Lin and Jiapeng Qu*. 2018. Gut microbiota in Tibetan herdsmen reflects the degree of urbanization. Frontiers in Microbiology 9:1745.

5. Guan-Hong Wang*, Bao-Fa Sun, Tuan-Lin Xiong, Yan-Kun Wang, Jin-Hua Xiao*, Da-Wei Huang*. 2016. Bacteriophage WO can mediate horizontal gene transfer in endosymbiotic Wolbachia genomes. Frontiers in Microbiology 7:1867.

4. Guan-Hong Wang, Ling-Yi Jia, Jin-Hua Xiao*, Da-Wei Huang*. 2016. Discovery of a novel Wolbachia supergroup in cave spider species and the lateral transfer of phage WO among distant hosts. Infection, Genetics and Evolution 41 (2016) 1–7.

3. Guan-Hong Wang, Jin-Hua Xiao*, Li-Ming Niu, Guang-Chang Ma, and Da-Wei Huang*. 2014. Large proportion of genes in a cryptic WO prophage genome are actively transcribing in an insect species with sex-specific patterns: involvement in Wolbachia biology and reproductive manipulation? BMC Genomics 15:893.

2. G.-H. Wang, J.-H. Xiao*, T.-L. Xiong, Z. Li, R. W. Murphy, and D.-W. Huang*. 2013. High-Efficiency Thermal Asymmetric Interlaced PCR (hiTAIL-PCR) for determination of a highly degenerated prophage WO genome in a Wolbachia strain infecting a fig wasp species. Applied and Environmental Microbiology 79:7476-7481.

1. Xiao, Jin-Hua^#; Yue, Zhen^#; Jia, Ling-Yi^#; Yang, Xin-Hua^#; Niu, Li-Hua^#; Wang, Zhuo^#; Zhang, Peng^#; Sun, Bao-Fa; He, Shun-Min; Li, Zi; Xiong, Tuan-Lin; Xin, Wen; Gu, Hai-Feng; Wang, Bo; Werren, John H.; Murphy, Robert W.; Wheeler, David; Niu, Li-Ming; Ma, Guang-Chang; Tang, Ting; Bian, Sheng-Nan; Wang, Ning-Xin; Yang, Chun-Yan; Wang, Nan; Fu, Yue-Guan; Li, Wen-Zhu; Yi, Soojin V.; Yang, Xing-Yu; Zhou, Qing; Lu, Chang-Xin; Xu, Chun-Yan; He, LiJuan; Yu, Li-Li; Chen, Ming; Zheng, Yuan; Wang, Shao-Wei; Zhao, Shuang; Li, Yan-Hong; Yu, Yang-Yang; Qian, Xiao-Ju; Cai, Yue; Bian, Lian-Le; Zhang, Shu; Wang, Jun-Yi; Yin, Ye; Xiao, Hui; Wang, Guan-Hong; Yu, Hui; Wu, Wen-Shan; Cook, James M.*; Wang, Jun*; Huang, Da-Wei*. 2013. Obligate mutualism within a host drives the extreme specialization of a fig wasp genome. Genome Biology 14:R141.

In Chinese

3. Ronger Zheng, He Jiang, Guan-Hong Wang*. 2023. The research progress of Wolbachia-based mosquito control. Chinese Bulletin of Entomology. accepted and in press.

2. Na Zhang, Man Zhao, Guan-Hong Wang*. 2022. Research progress on microorganism against pest and disease. Journal of Plant Protection 49(1):220-230.

1. Wei-Hua Li, He Jiang, Guan-Hong Wang*. 2022. The progress in prevention and control of mosquito based on microorganism and gene editing. Journal of Plant Protection 49(1)：231-239.

Patent

1. Robert M. Brucker and Guan-Hong Wang. 2019. “Bacterial Probiotic to Detoxify Herbicides and Insecticides” (U.S. Patent No.: US 2019/0321417 A1). Equal inventorship.

Selected Presentations:

Guan-Hong Wang, 2023. Function exploiting of insect microbiota and vector insect control. Nanjing Agricultural University, Nanjing, China.

Guan-Hong Wang, 2023. Function exploiting of insect microbiota and vector insect control. Plant Protection Institute of Jiangsu Academy of Agricultural Sciences, Nanjing, China.

Guan-Hong Wang, 2023. Holobiont perspectives on tripartite interactions among microbiota, mosquitoes, and pathogens. ICIS 2023, Baoding, China.

Guan-Hong Wang, 2023. Nasonia-microbiome associations: a model for evolutionary hologenomics research. 5th Nasonia Conference, Minster, Germany.

Guan-Hong Wang, 2023. Function exploiting of insect microbiota and vector insect control. Guiyang University, Guiyang, China.

Guan-Hong Wang, 2023. Function exploiting of insect microbiota and vector insect control. 13th Young Scholars Symposium of the Chinese Insect Society, Guiyang, China.

Guan-Hong Wang, 2023. Function exploiting of insect microbiota and vector insect control. Hebei Normal University, Shijiazhuang, China.

Guan-Hong Wang, 2023. Symbiotic and genetic strategies to combat vector-borne disease. 1st WDRN symposium,Hainan, China.

Guan-Hong Wang, 2023. Function exploiting of insect microbiota and vector insect control. Guangxi Medical University, Nanning, China.

Guan-Hong Wang, 2023. Function exploiting of insect microbiota and vector insect control. Plant Protection Institute of Guangxi Academy of Agricultural Sciences, Nanning, China.

Guan-Hong Wang, 2023. Function exploiting of insect microbiota and vector insect control. Guangxi Medical University, Nanning, China.

Guan-Hong Wang, 2023. Function exploiting of insect microbiota and vector insect control. Capital Normal University, Beijing, China.

Guan-Hong Wang, 2023. Function exploiting of insect microbiota and vector insect control. Beijing Forestry University, Beijing, China.

Guan-Hong Wang, 2023. Function exploiting of insect microbiota and vector insect control. Southwest University, online, China.

Guan-Hong Wang, 2023. Nasonia-microbiome associations: a model for evolutionary hologenomics research. China Intestinal Congress, Beijing, China.

Guan-Hong Wang, 2023. The Third Expert Committee Meeting on Insect Microbiome,Beijing, China.

Guan-Hong Wang, 2023. Function exploiting of insect microbiota and vector insect control. Shenyang Agricultural University, Liaoning, China.

Guan-Hong Wang, 2022. Function exploiting of insect microbiota. The Third National Symposium on Insect Microbiomics Meeting, online, China.

Guan-Hong Wang, 2022. Function exploiting of insect microbiota. Vazyme Biotech Co., online, China.

Guan-Hong Wang, 2022. Function exploiting of insect microbiota. Sun Yat-sen University, online, China.

Guan-Hong Wang, 2022. Function exploiting of insect microbiota and vector insect control. Enthusiasm Research Institute, online, China.

Guan-Hong Wang, 2022. Function exploiting of insect microbiota and vector insect control. Science Summit Lecture Hall, online, China.

Guan-Hong Wang, 2022. Function exploiting of insect microbiota and vector insect control. Ecological and Nature Conservation Institute, Chinese Academy of Forestry, online, China.

Guan-Hong Wang, 2022. Function exploiting of insect microbiota and vector insect control. Henan Agricultural University, online, China.

Guan-Hong Wang, 2022. Function exploiting of insect microbiota and vector insect control. Anhui Normal University, online, China.

Guan-Hong Wang, 2022. Function exploiting of insect microbiota and vector insect control. Microecology, online, China.

Guan-Hong Wang, 2022. Function exploiting of insect microbiota and vector insect control. Tobacco research institute of Chinese academy of agricultural sciences, online, China.

Guan-Hong Wang, 2021. Function and structural stability regulation of insect microbiota. China Agricultural University, Beijing, China (Invited talk, full travel support).

Guan-Hong Wang, 2021. Function and structural stability regulation of insect microbiota. Institute of plant protection, Chinese Academy of Agricultural Sciences, Beijing, China (Invited talk, full travel support).

Guan-Hong Wang, 2021. Function exploiting of insect microbiota and vector insect control. Beijing Normal University, Beijing, China (Invited talk, full travel support).

Guan-Hong Wang, 2021. Function and structural stability regulation of insect microbiota. Sun Yat-sen University, Guangzhou, China (Invited talk, full travel support).

Guan-Hong Wang, 2021. Function and structural stability regulation of insect microbiota. South China Agricultural University, Guangzhou, China (Invited talk, full travel support).

Guan-Hong Wang, 2021. Function and structural stability regulation of insect microbiota. Institute of Zoology, Guangdong Academy of Sciences, China (Invited talk, full travel support).

Guan-Hong Wang, 2021. Function and structural stability regulation of insect microbiota. Institute of bioengineering, Guangdong Academy of Sciences, China (Invited talk, full travel support).

Guan-Hong Wang, 2021. Function exploiting of insect microbiota and vector insect control. Huazhong Agricultural University, Wuhan, China (Invited talk, full travel support).

Guan-Hong Wang, 2021. Function exploiting of insect microbiota and vector insect control. Central China Normal University, Wuhan, China (Invited talk, full travel support).

Guan-Hong Wang, 2021. Function exploiting of insect microbiota and vector insect control. Hubei University, Wuhan, China (Invited talk, full travel support).

Guan-Hong Wang, 2021. Function exploiting of insect microbiota and vector insect control. The 8th National Symposium on microbial genomics, Wuhan, China (Invited talk, full travel support).

Guan-Hong Wang, 2021. Function and structural stability regulation of insect microbiota. Hebei University, Baoding, China (Invited talk, full travel support).

Guan-Hong Wang, 2021. Function and structural stability regulation of insect microbiota. Hebei Agricultural University, Baoding, China (Invited talk, full travel support).

Guan-Hong Wang, 2021. Function exploiting of insect microbiota and vector insect control. Hebei Normal University, Shijiazhuang, China (Invited talk, full travel support).

Guan-Hong Wang, 2021. Can microbes accelerate host species differentiation? The 17th National Symposium on insect fauna classification and the 5th Symposium on pollinators, Tianjin, Beijing, China (Invited talk).

Guan-Hong Wang, 2021. Function exploiting of insect microbiota and vector insect control. National Postdoctoral Forum on plant protection, Hohhot, China (Invited talk, full travel support).

Guan-Hong Wang, 2021. Function exploiting of insect microbiota and vector insect control. Inner Mongolia Agricultural University, Hohhot, China (Invited talk, full travel support).

Guan-Hong Wang, 2021. Function exploiting of insect microbiota and vector insect control. 2021 National Symposium on biological pest control, Shenyang, China (Invited talk).

Guan-Hong Wang, 2021. Function exploiting of insect microbiota and vector insect control. 2021 academic annual meeting of the Chinese entomological society, Xi'an, China (Key note speaker).

Guan-Hong Wang, 2021. Function exploiting of insect microbiota and vector insect control. Shaanxi Normal University, Xi'an, China (Invited talk).

Guan-Hong Wang, Robert M. Brucker 2019. Functional microbiota in chemical toxicity resistance and genotype selection to their host. University of Pennsylvania, Philadelphia, United States (Invited talk, full travel support).

Guan-Hong Wang, Robert M. Brucker 2019. Functional microbiota in chemical toxicity resistance and genotype selection to their host. University of Chicago, Chicago, United States (Invited talk, full travel support).

Guan-Hong Wang, Robert M. Brucker 2019. Functional microbiota in chemical toxicity resistance and genotype selection to their host. Carnegie Institution for Science, Maryland, United States (Invited talk, full travel support).

Guan-Hong Wang, Robert M. Brucker 2019. Functional microbiota in chemical toxicity resistance and genotype selection to their host. University of Georgia, Athens, United States (Invited talk, full travel support).

Guan-Hong Wang, Robert M. Brucker 2019. Long-term experimental test microbiota can be a selection unit to host genotype. Ecological and Evolutionary Genomics Conference, Manchester, United States (Poster).

Guan-Hong Wang, Robert M. Brucker 2019. Long-term experimental test microbiota can be a selection unit to host genotype. Annual MIT-Harvard Microbiome Symposium, Manchester, United States (Invited poster).

Guan-Hong Wang, Robert M. Brucker 2018. Long-term exposure to pesticides changes function of microbiome, accelerating selection on host populations. American Society for Microbiology Conference, Atlanta, United States (Poster).

Guan-Hong Wang, Robert M. Brucker 2017. Long-term exposure to pesticides changes function of microbiome, accelerating selection on host populations. Harvard FAS Postdoc Research Symposium, Boston, United States (Poster).

Guan-Hong Wang, Robert M. Brucker 2017. Long-term exposure to pesticides changes function of microbiome, accelerating selection on host populations. Multi-omics for Microbiomes – EMSL Integration Conference, Pasco, United States (Poster).

Guan-Hong Wang, Jin-Hua Xiao, Da-Wei Huang 2016. Phage function in symbiont and insect host. Harvard University, Boston, United States (Invited talk, full travel support).

Guan-Hong Wang, Tyler Schleicher, Jing Yang, Erol Fikrig 2016. A mosquito protein facilitates Plasmodium sporozoite survival in the vertebrate host. Yale School of Public Health, New Haven, United States (Invited talk, full travel support).

Guan-Hong Wang, Jin-Hua Xiao, Da-Wei Huang 2014. Sex-specific transcription of large proportion of genes in the only cryptic WO prophage genome in a fig wasp species. 8th International Wolbachia Conference, Innsbruck, Austria (Talk).

Guan-Hong Wang, Jin-Hua Xiao, Da-Wei Huang 2014. Bacteriophage, an important genetic vector player in the intracellular arena. The 3rd Session of the National Virology Graduate Forum, Wuhan, China (Talk).

Guan-Hong Wang, Jin-Hua Xiao, Da-Wei Huang 2014. Role of phage WO to Wolbachia, and even insect host. Graduate Forum, Beijing, China (Poster).

Honors & Awards:

Selected Grants Awarded

Gut microbiome-host interactions and pest control based on microbes and gene editing (PI, Talent Project of Chinese Academy of Sciences, 300,0000, 2021/02-2027/02)

Development and application of novel vector insect control technology based on microbial and gene editing (PI, Overseas Excellent Youth Program of the National Natural Science Foundation of China, 200,0000, 2022/01-2024/12)

Developing innovative symbiont and genetic tools to control a major invasive disease vector, Aedes aegypti (PI, CAS-CSIRO Partnership Joint Project, 94,0000, 2022/01-2024/12)

Research on the correlation between human gut flora and diseases (coPI, The National Key R&D Program of China, 375,0000, 2022/11-2026/10)

Physiological regulation mechanism of Nasonia vitripennis intestinal microbial community under pesticide stress (PI, the National Science Foundation of China, 54,0000, 2023/01-2026/12)

Development of probiotics for Nasonia vitripennis, construction of parthenogenetic strains, and applications of natural enemy control for pest (PI, High tech industrialization special project of science and technology cooperation between Jilin Province and Chinese Academy of Science, 40,0000, 2022/10-2024/10)

Research on the molecular mechanism of Nasonia vitripennis regulating symbiotic microbial communities (PI, The Natural Science Foundation of Beijing, 20,0000, 2022/01-2024/12)

Symbiotic invasion project 4 (coPI, The National Key R&D Program of China, 106,0000, 2022/11-2026/10)

Physiological regulatory mechanisms of the intestinal microbial community of Nasonia vitripennis under environmental stress conditions (PI, Chinese Academy of Sciences pilot project, 15,0000, 2021/06-2022/05)

Peer Reviewer:

Trends in Biotechnology, Trends in Cell Biology, BMC Ecology and Evolution, Protein & Cell, Development Genes and Evolution, Microbial Ecology, Microbiology Spectrum, BMC Genomics, International Journal of Molecular Sciences, Ecological Entomology, Insect Science, Insects, Journal of Economic Entomology, Life, Frontiers in Microbiology, Frontiers in Genetics, Tropical Medicine and Infectious Disease, Viruses, Pollutants, Journal of Animal Ecology, Molecular & Biochemical Parasitology, Biomolecules, PLOS ONE, JoVE, Acta Microbiologica Sinica, Journal of Plant Protection, Microbiology China, Hereditas (Beijing)

Editorial Board:

mSystems (2023- ), Frontiers in Immunology (2022- ), Frontiers in Microbiology (2022- ), iMeta (2021- ), Acta Microbiologica Sinica (2021- ), Journal of Plant Protection (2021- ), Microbiology China (2022- ), Modern Agriculture (2022- ), Acta Entomologica Sinica (2023- ),

Mentorship:

As of November 2023, the wanglab.com.cn consists of: One Laboratory Manager (He Jiang) ---- Four Postdoctoral Scholar (Yan-Jun Liu, Ph.D.; Qiqi Wang, Ph.D.; Dan-Dan Wang, Ph.D.; Run-Biao Wu, Ph.D.;) ----Ten Graduate Students (Rong-Er Zheng B.S.; Ying Li B.S.; Jian-Qiu Cheng B.S.; Zheng-Yu Zhu B.S.; Jia-Hui Wu B.S.; Xi Guo B.S.; Hong-Xin Wu B.S.; Long-Yang Wang B.S.; Ting-Ting Zhang B.S.; Ying-Qiao Ran B.S.;).

For an updated list of active lab members (http://www.wanglab.com.cn/About.aspx?ClassID=29).

In addition to the active members, we have ~5 alumni consisting of former Postdocs, Students,

visiting scientists, lab techs etc.

Membership:

Member of Insect-Microbiota Community, The Entomological Society of China (2023-)

Member of Young Community, The Entomological Society of China (2023-)

Member of Microbiota Community, Chinese Society for Microbiology (2023-)

Member of Medical Insect Community, The Entomological Society of China (2023-)

Member of Insect-Genome Community, The Entomological Society of China (2023-)

Member of Insect-Development & Genetics Community, The Entomological Society of China (2023-)

Member of International Communication Community, The Entomological Society of China (2023-)

Member of Young Community, The International Society of Zoological Sciences (2023-)

American Society for Microbiology (2018-2019)

Beijing Pesticide Society (2021-)

The Entomological Society of China (2021-)

Beijing Entomological Society (2021-)

International Society of Zoological Sciences (2022-)