I started my research career working on co–evolution between phage WO and endosymbiont bacteria Wolbachia at Institute of Zoology, Chinese Academy of Sciences. Then I got a fellowship supporting me to work on malaria vaccine project at Yale University. I did my postdoc working on host-microbe interactions at Harvard University and using advanced genetic and symbiotic technologies for mosquito control at University of California, San Diego. My lab current research continues to focus on animal-microbe interactions and genetic technologies for mosquito–borne diseases control.
It is mainly engaged in the research of plant disease epidemic and comprehensive control, focusing on pathogen identification and comprehensive control of Korla Fragrant Pear branch blight, identifying the pathogen causing fragrant pear branch blight in Korla, and forming a complete set of comprehensive prevention and control technology system.
Regulation and utilization of microbial metabolism: Analysis and explanation of the microbial gene expressions and metabolic characteristics in cooperated with the host using single cell sequencing, metagenomics and metabolomics. Utilization of engineering bacteria for controlling insects was studied through the isolation and functional aspects. To explore the gene regulation mechanism of microorganism and mosquito symbiosis.
My research focus has been understanding the role of microorganisms that interact with insect hosts; specially, using insects (jewel wasp; bees; fruit borers) to determine the molecular and physiological mechanism of host regulation of microorganisms. The long-term goals of research are discovering theories of insect microbial adaptation, along with developing innovative techniques and strategies for green prevention and pest management.
Insecticides resistance has become widespread in mosquito, reducing pesticide efficacy and increasing financial expenditure. One pattern of pesticide resistance mechanisms is symbiont-mediated detoxification within insect pests. I aim to explore detoxification modulated by symbiotic associations between bacteria and mosquitoes, as well as the development of new strategy for mosquito control.